The wildshiners of Best Virginia make bioengineering seem like magic, whipping up incredible hybrid creatures like rhinoporcupines and exotic environments straight out of a fairy tale. But the genebillies of the prank-loving Dozen family take it too far when they start out wrecking a wedding and end up bringing on the apocalypse. "Till death do us part" will come a lot sooner than expected—for the whole damn world—unless the bride, Vicky Dozen, can use her wildshiner skills to weave together what her whack-job brothers have torn asunder. But first, she must solve the ultimate mystery, bringing to light the deepest secret of her family, a secret rooted in the very genetic material that gives her life meaning.