This text looks at various aspects of receptor-mediated steroid hormone action and the influence of synthetic antagonists on these processes in normal and disease states. Also discussed are the synthesis, pharmacology, physiology and biochemistry of antisteroids being developed for potential use as clinical adjuncts against hormone-based dysfunctions in the human subject. These papers were presented at a conference held by the New York Academy of Sciences on 20-23 September, 1994, in Texas, USA.